Does Mounjaro have worse side effects than Ozempic?

Not necessarily. Both commonly cause gastrointestinal symptoms. In a direct comparison, nausea, diarrhea, and vomiting occurred with both medications, with some side effects becoming more common at higher tirzepatide doses.(( Frías JP, Davies MJ, Rosenstock J, et al . Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes . New England Journal of Medicine. 2021;385:503–515. doi:10.1056/NEJMoa2107519.))

What is the most common side effect of Ozempic?

Nausea is among the most frequently reported Ozempic side effects. Vomiting, diarrhea, abdominal pain, and constipation are also common.(( U.S. Food and Drug Administration . Ozempic (semaglutide) Prescribing Information ))

What is the most common side effect of Mounjaro?

Nausea and diarrhea are among the most frequently reported Mounjaro side effects. Decreased appetite, vomiting, constipation, indigestion, and abdominal pain are also common.(( U.S. Food and Drug Administration . Mounjaro (tirzepatide) Prescribing Information ))

Can Ozempic or Mounjaro cause pancreatitis?

Yes. Mounjaro carries a warning for acute pancreatitis.(( U.S. Food and Drug Administration . Mounjaro (tirzepatide) Prescribing Information )) Ozempic also carries a warning for acute pancreatitis.(( U.S. Food and Drug Administration . Ozempic (semaglutide) Prescribing Information )) Seek medical attention for severe, persistent abdominal pain, especially if it radiates to the back.