What is the normal metformin dosage for adults?

Immediate-release metformin commonly starts at 500 mg twice daily or 850 mg once daily with meals. Extended-release metformin commonly starts at 500 mg once daily with the evening meal. The dose can then be gradually increased based on blood sugar response and tolerability.

What is the maximum metformin dosage per day?

The maximum recommended dose for standard immediate-release metformin is generally 2,550 mg per day in divided doses. Many extended-release formulations have a maximum recommended dose of 2,000 mg once daily. Maximum doses can vary by product.

Is 1,000 mg of metformin a high dose?

A total of 1,000 mg per day is within commonly prescribed adult metformin dosing ranges and is below the usual maximum daily dose. Whether 1,000 mg is appropriate depends on the formulation, blood sugar response, side effects, kidney function, and your prescribed treatment plan.

Can you take 2,000 mg of metformin at once?

Some extended-release metformin products may be prescribed at 2,000 mg once daily, typically with the evening meal. Immediate-release metformin at higher daily doses is generally divided throughout the day. Follow the instructions for your specific prescription and formulation.

Does metformin dosage change with kidney function?

Kidney function can affect whether metformin should be started or continued. Starting metformin is not recommended when eGFR is between 30 and 45 mL/min/1.73 m², and metformin is contraindicated when eGFR is below 30. Kidney function should be monitored during treatment.

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Metformin Dosage: Starting, Maximum and Daily Doses
ByResearch Team September 21, 2025August 11, 2026

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