Question 1

Can Ozempic cause low blood sugar?

Accepted Answer

Ozempic has a relatively low hypoglycemia risk when used alone. The risk increases when it is combined with insulin or a sulfonylurea.((Novo Nordisk. Ozempic (semaglutide) Prescribing Information. Current U.S. prescribing information.))

Question 2

Can Mounjaro cause low blood sugar?

Accepted Answer

Yes. Mounjaro can contribute to hypoglycemia, especially when used with insulin or a sulfonylurea.((Eli Lilly and Company. Mounjaro (tirzepatide) Prescribing Information. Current U.S. prescribing information.))

Question 3

Can Wegovy cause hypoglycemia?

Accepted Answer

Wegovy can lower glucose, and the risk of hypoglycemia is higher when it is used with insulin or insulin secretagogues such as sulfonylureas.((Novo Nordisk. Wegovy (semaglutide) Prescribing Information. Current U.S. prescribing information.))

Question 4

Why am I getting low blood sugar after starting a GLP-1 medication?

Accepted Answer

Possible reasons include continuing the same insulin or sulfonylurea dose despite improved glucose levels, eating smaller meals, or other changes in diabetes management.

Question 5

Should insulin be reduced when starting a GLP-1 medication?

Accepted Answer

Sometimes, but not automatically. ADA guidance recommends reassessing insulin dosing when GLP-1–based therapy is added or intensified.((American Diabetes Association Professional Practice Committee. Pharmacologic Approaches to Glycemic Treatment: Standards of Care in Diabetes—2026. Diabetes Care. 2026;49(Suppl 1).))

Question 6

Do GLP-1 medications cause low blood sugar in people without diabetes?

Accepted Answer

Hypoglycemia is uncommon when GLP-1–based therapy is used without insulin or another medication that independently lowers glucose. Repeated or symptomatic low glucose should be medically evaluated.

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